| Thursday, 15 April 2004 | ||
| Organisers | F.L.J. Visseren (Utrecht, The Netherlands) P. Nielsen (Hamburg, The Netherlands |
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| Sponsors | Apotex Inc. (Ontario, Canada) Thalassaemia International Federation (Nicosia, Cyprus) European Iron Club International Bioiron Society Associazione per la Ricerca “Piera Cutino” (Italy) Schwarz Pharma (Monheim, Germany) |
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Cardiovascular diseases: new horizons for iron chelator treatment
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| Session I | Iron and atherosclerosis | Thursday morning |
| Chairs | G. Fiorelli (Milan, Italy) P. Nielsen (Hamburg, Germany) |
abstract number |
| 08.30 – 09.10 | Atherosclerosis, a multi-facetted disease; an overview of current concepts F.L.J. Visseren (Utrecht, The Netherlands) |
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| 09.10 – 09.35 | Are the serum ferritin, folate, and uric acid associated with coronary heart disease in northern Chinese? L.-H. Xu, W. Li, T.-K. Liu, S.-J. Wu, H.-Y. Ma, X.-M. Yuan (Jilin City, China; Linköping , Sweden) |
109 |
| 09.35 – 10.00 | HFE-gene mutations and iron parameters in women with incident coronary heart disease (CORA-STUDY) P. Nielsen, B. Zyriax, R. Fischer, H. Boeing, and E. Windler (Hamburg, Germany; Bergholz-Rehbrücke, Germany) |
110 |
| 10.00 – 11.15 | coffee break + plenary lecture | |
| Session II | Deleterious effects of iron on the vasculature | |
| Chairs | P. Nielsen (Hamburg, Germany) F.L.J. Visseren (Utrecht, The Netherlands) |
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| 11.30 – 12.10 | Labile iron inside and outside cells: biological, toxicological and therapeutic implications Z.I. Cabantchik (Jerusalem, Israel) |
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| 12.10 – 12.35 | EDTA enhances non-transferrin bound iron effects on the expression of endothelial adhesion molecules A.E.R. Kartikasari, N.A. Georgiou, F.L. J. Visseren, H. van Kats-Renaud, B.S. van Asbeck, and J.J. M. Marx (Utrecht, The Netherlands) |
112 |
| 12.35 – 13.00 | Serum levels ICAM-1 in thalassemic patients A. Meo, B. Piraino, M.V. Merlino, C. Cuppari, G. Muscolino, M.C. Cutrupi, A. Burgo, L. Rigoli, and C. Salpietro (Messina, Italy) |
113 |
| 13.00 – 14.45 | lunch / poster viewing / exhibition + plenary lecture | |
| Session III | Iron chelation in vascular disease prevention | Thursday afternoon |
| Chairs | C.T. Peng (Taichung, Taiwan) F.L.J. Visseren (Utrecht, The Netherlands) |
abstract number |
| 15.00 – 15.40 | Iron cardiotoxicity: protective factors and iron chelation A. Piga (Turin, Italy) |
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| 15.40 – 16.00 | Introduction of deferiprone in thalassaemia patients with cardiac iron overload not responding to deferoxamine D. Yazman, A. Kolnagou, C. Economides, J. A. Moutiris, and G.J. Kontoghiorghes (Nicosia, Turkish Cyprus; Limassol, Cyprus) |
114 |
| 16.00 – 16.30 | coffee break | |
| Session IV | Pro and con debate on iron and atherosclerosis | |
| Chair | J.J.M. Marx (Utrecht, The Netherlands) | |
| 16.30 – 16.50 | Current status of the hypothesis that iron depletion protects against ischemic heart disease J.L. Sullivan (Gainesville, FL, USA) |
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| 16.50 – 17.10 | Iron is not involved in atherogenesis P. Nielsen (Hamburg. Germany) |
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| 17.10 – 17.25 | Why rejection of a role for iron in atherogenesis is unjustified J.L. Sullivan (Gainesville, FL, USA) |
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| 17.25 – 18.00 | Round table discussion P. Nielsen (Hamburg, Germany) A. Piga (Turin, Italy) J. Sullivan (Gainesville, FL, USA) |
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| 18.00 | End of workshop | |
| Posters | ||
| Non-Transferrin-Bound-Iron in subjects with normal transferrin saturation D.L. van der A, N.A.Georgiou, J.H.van Kats-Renaud, J.J.M. Marx, D.E. Grobbee, and Y.T. van der Schouw (Utrecht, The Netherlands) |
111 | |
| Effect of iron on monocyte attachment to microorganism-infected human endothelial cells N.A. Georgiou, A.E. R. Kartikasari, M.C. de Geest, J.J.M. Bouwman, F.L.J. Visseren, B.S. van Asbeck, and J.J. M. Marx (Utrecht, The Netherlands) |
115 | |
| Non-Transferrin Bound Iron alters adhesion of human monocytes to human vascular endothelium under shear stress A.E.R. Kartikasari, N.A. Georgiou, S. van Mullekom, F.L.J. Visseren, H. van Kats-Renaud, B.S. van Asbeck, and J.J.M. Marx (Utrecht, The Netherlands) |
116 | |
| Comparison of MRI T2 and MRI T2* in the diagnosis of cardiac iron load in thalassaemia patients C. Economides, E. Eracleous, D. Yazman, A. Kolnagou, and G.J. Kontoghiorghes (Limassol, Cyprus) |
117 | |
| How relevant are serum ferritin levels and MRI T2* for assessing cardiac iron load in thalassaemia A. Kolnagou, D. Yazman, C. Economides, E. Eracleous, and G.J. Kontoghiorghes (Nicosia, Turkish Cyprus; Paphos, Limassol, Cyprus) |
118 | |
| Flavonoids of Garcinia kola seeds inhibited Fe/ ascorbate- induced oxidation of human LDL in vitro: a comparative study O.A. Adaramoye, E.O. Farombi, E.O. Adeyemi, and G.O. Emerole (Ibadan, Al Ain, Nigeria) |
119 | |
