Thursday, 15 April 2004
Organisers F.L.J. Visseren (Utrecht, The Netherlands)
P. Nielsen (Hamburg, The Netherlands
Sponsors Apotex Inc. (Ontario, Canada)
Thalassaemia International Federation (Nicosia, Cyprus)
European Iron Club
International Bioiron Society
Associazione per la Ricerca “Piera Cutino” (Italy)
Schwarz Pharma (Monheim, Germany)

Cardiovascular diseases: new horizons for iron chelator treatment
ICOC workshop

Session I Iron and atherosclerosis Thursday morning
Chairs G. Fiorelli (Milan, Italy)
P. Nielsen (Hamburg, Germany)
abstract number
08.30 – 09.10 Atherosclerosis, a multi-facetted disease; an overview of current concepts
F.L.J. Visseren (Utrecht, The Netherlands)
09.10 – 09.35 Are the serum ferritin, folate, and uric acid associated with coronary heart disease in northern Chinese?
L.-H. Xu, W. Li, T.-K. Liu, S.-J. Wu, H.-Y. Ma, X.-M. Yuan (Jilin City, China; Linköping , Sweden)
09.35 – 10.00 HFE-gene mutations and iron parameters in women with incident coronary heart disease (CORA-STUDY)
P. Nielsen, B. Zyriax, R. Fischer, H. Boeing, and E. Windler (Hamburg, Germany; Bergholz-Rehbrücke, Germany)
10.00 – 11.15 coffee break + plenary lecture
Session II Deleterious effects of iron on the vasculature
Chairs P. Nielsen (Hamburg, Germany)
F.L.J. Visseren (Utrecht, The Netherlands)
11.30 – 12.10 Labile iron inside and outside cells: biological, toxicological and therapeutic implications
Z.I. Cabantchik (Jerusalem, Israel)
12.10 – 12.35 EDTA enhances non-transferrin bound iron effects on the expression of endothelial adhesion molecules
A.E.R. Kartikasari, N.A. Georgiou, F.L. J. Visseren, H. van Kats-Renaud, B.S. van Asbeck, and J.J. M. Marx (Utrecht, The Netherlands)
12.35 – 13.00 Serum levels ICAM-1 in thalassemic patients
A. Meo, B. Piraino, M.V. Merlino, C. Cuppari, G. Muscolino, M.C. Cutrupi, A. Burgo, L. Rigoli, and C. Salpietro (Messina, Italy)
13.00 – 14.45 lunch / poster viewing / exhibition + plenary lecture
Session III Iron chelation in vascular disease prevention Thursday afternoon
Chairs C.T. Peng (Taichung, Taiwan)
F.L.J. Visseren (Utrecht, The Netherlands)
abstract number
15.00 – 15.40 Iron cardiotoxicity: protective factors and iron chelation
A. Piga (Turin, Italy)
15.40 – 16.00 Introduction of deferiprone in thalassaemia patients with cardiac iron overload not responding to deferoxamine
D. Yazman, A. Kolnagou, C. Economides, J. A. Moutiris, and G.J. Kontoghiorghes (Nicosia, Turkish Cyprus; Limassol, Cyprus)
16.00 – 16.30 coffee break
Session IV Pro and con debate on iron and atherosclerosis
Chair J.J.M. Marx (Utrecht, The Netherlands)
16.30 – 16.50 Current status of the hypothesis that iron depletion protects against ischemic heart disease
J.L. Sullivan (Gainesville, FL, USA)
16.50 – 17.10 Iron is not involved in atherogenesis
P. Nielsen (Hamburg. Germany)
17.10 – 17.25 Why rejection of a role for iron in atherogenesis is unjustified
J.L. Sullivan (Gainesville, FL, USA)
17.25 – 18.00 Round table discussion
P. Nielsen (Hamburg, Germany)
A. Piga (Turin, Italy)
J. Sullivan (Gainesville, FL, USA)
18.00 End of workshop
Non-Transferrin-Bound-Iron in subjects with normal transferrin saturation
D.L. van der A, N.A.Georgiou, J.H.van Kats-Renaud, J.J.M. Marx, D.E. Grobbee, and Y.T. van der Schouw (Utrecht, The Netherlands)
Effect of iron on monocyte attachment to microorganism-infected human endothelial cells
N.A. Georgiou, A.E. R. Kartikasari, M.C. de Geest, J.J.M. Bouwman, F.L.J. Visseren, B.S. van Asbeck, and J.J. M. Marx (Utrecht, The Netherlands)
Non-Transferrin Bound Iron alters adhesion of human monocytes to human vascular endothelium under shear stress
A.E.R. Kartikasari, N.A. Georgiou, S. van Mullekom, F.L.J. Visseren, H. van Kats-Renaud, B.S. van Asbeck, and J.J.M. Marx (Utrecht, The Netherlands)
Comparison of MRI T2 and MRI T2* in the diagnosis of cardiac iron load in thalassaemia patients
C. Economides, E. Eracleous, D. Yazman, A. Kolnagou, and G.J. Kontoghiorghes (Limassol, Cyprus)
How relevant are serum ferritin levels and MRI T2* for assessing cardiac iron load in thalassaemia
A. Kolnagou, D. Yazman, C. Economides, E. Eracleous, and G.J. Kontoghiorghes (Nicosia, Turkish Cyprus; Paphos, Limassol, Cyprus)
Flavonoids of Garcinia kola seeds inhibited Fe/ ascorbate- induced oxidation of human LDL in vitro: a comparative study
O.A. Adaramoye, E.O. Farombi, E.O. Adeyemi, and G.O. Emerole (Ibadan, Al Ain, Nigeria)