3 – 4 April 2003
Organizers A. Pietrangelo (Modena, Italy)
J.J.M. Marx (Utrecht, The Netherlands)
Sponsors European Commission QLRT-2001-00444
Novartis Pharma

Iron toxicity in iron overload diseases: chemical, biological and medical aspects

Session I Thursday
Chairs A. Pietrangelo (Modena, Italy) & A. McKie (London, UK) Abstract No.
9.40 Welcome and introduction
A. Pietrangelo (Modena, Italy)
9.50 – 10.30 Regulation of iron metabolism
J.J.M. Marx (Utrecht, The Netherlands)
10.30 -11.00 Genes involved in iron absorption and trafficking
A. McKie (London, UK)
11.00 – 11.15 coffee break
Session II
Chairs P. Brissot (Rennes, France) & F. Visseren (Utrecht, The Netherlands) Abstract No.
11.15 – 11.45 Hemochromatosis
P. Brissot (Rennes, France)
12.15 – 12.45 Hepcidin in iron metabolism
O. Loreal (Rennes, France)
12.45 – 13.00 Discussion
13.00 End of Session II
13.00 – 14.00 Lunch / poster viewing
Session III
Chairs J.J.M. Marx (Utrecht, The Netherlands) & Y. van der Schouw (Utrecht, The Netherlands) Abstract No.
15.00 – 15.15 Iron in cardiovascular diseases, epidemiological aspects
Y. van der Schouw (Utrecht, The Netherlands)
15.15 – 15.30 Iron in cardiovascular diseases, medical aspects
F.L.J. Visseren (Utrecht, The Netherlands)
15.30 – 15.45 Iron in cardiovascular diseases, biological aspects
N. Georgiou (Utrecht, The Netherlands)
15.45 – 16.00 Dietary heme iron and coronary heart disease
D.L. van der A, P.H.M. Peeters, D.E. Grobbee, and Y.T. van der Schouw (Utrecht, The Netherlands)
16.00 – 16.15 Iron modulates monocyte adherence to human endothelial cell monolayer
A.E.R. Kartikasari, N.A. Georgiou, H. van Kats-Renaud, F.L.J. Visseren, B.S. van Asbeck, and J.J.M Marx (Utrecht, The Netherlands)
16.15 – 16.30 coffee break
Session IV
Chairs Z.I. Cabantchik (Jerusalem, Israel) & R.C. Hider (London, UK) Abstract No.
16.30 – 17.00 Non Transferrin Bound Iron: its nature and measurement
R.C. Hider, and D.Y. Liu (London, UK)
17.00 – 17.30 Labile Plasma Iron (LPI), a novel indicator of chemically reactive iron in iron-overload
B. P. Esposito, W. Breuer, and Z.I. Cabantchik (Jerusalem, Israel)
17.30 – 18.00 Discussion
18.00 End of Session IV
Session V Friday
Chairs P. Aisen (New York, USA) & W. Koppenol (Zürich, Switzerland) Abstract No.
9.40 – 10.10 The uses and hazards of iron: a review of mechanisms and defenses
P. Aisen (New York, USA)
10.10 – 10.35 Iron and redox cycling
D. Hofstetter, R. Kissner, and W.H. Koppenol (Zürich, Switzerland)
10.35 – 11.00 Iron and radical reactions
M. Merkhofer, R. Kissner, A. Vanin, and W.H. Koppenol (Zürich, Switzerland)
11.00 – 11.15 coffee break
Session VI
Chairs J.J.M. Marx (Utrecht, The Netherlands) & A. Pietrangelo (Modena, Italy) Abstract No.
11.15 – 11.45 Development of orally active iron chelators for the treatment of thalassaemia
R.C. Hider, and Z.D. Liu (London, UK)
11.45 – 12.05 Update on the clinical development of the new oral iron chelator ICL670
D. Alberti (Origgio, Italy)
12.05 – 13.00 Round table discussion on toxicity of iron in biological fluids
P. Aisen (New York, USA)W.H. Koppenol (Zürich, Switzerland)R.C. Hider (London, UK)Z.I. Cabantchik (Jerusalem, Israel)
13.00 End of workshop