3 – 4 April 2003 | ||
Organizers | A. Pietrangelo (Modena, Italy) J.J.M. Marx (Utrecht, The Netherlands) |
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Sponsors | European Commission QLRT-2001-00444 Novartis Pharma |
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Iron toxicity in iron overload diseases: chemical, biological and medical aspects |
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Session I | Thursday | |
Chairs | A. Pietrangelo (Modena, Italy) & A. McKie (London, UK) | Abstract No. |
9.40 | Welcome and introduction A. Pietrangelo (Modena, Italy) |
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9.50 – 10.30 | Regulation of iron metabolism J.J.M. Marx (Utrecht, The Netherlands) |
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10.30 -11.00 | Genes involved in iron absorption and trafficking A. McKie (London, UK) |
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11.00 – 11.15 | coffee break | |
Session II | ||
Chairs | P. Brissot (Rennes, France) & F. Visseren (Utrecht, The Netherlands) | Abstract No. |
11.15 – 11.45 | Hemochromatosis P. Brissot (Rennes, France) |
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12.15 – 12.45 | Hepcidin in iron metabolism O. Loreal (Rennes, France) |
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12.45 – 13.00 | Discussion | |
13.00 | End of Session II | |
13.00 – 14.00 | Lunch / poster viewing | |
Session III | ||
Chairs | J.J.M. Marx (Utrecht, The Netherlands) & Y. van der Schouw (Utrecht, The Netherlands) | Abstract No. |
15.00 – 15.15 | Iron in cardiovascular diseases, epidemiological aspects Y. van der Schouw (Utrecht, The Netherlands) |
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15.15 – 15.30 | Iron in cardiovascular diseases, medical aspects F.L.J. Visseren (Utrecht, The Netherlands) |
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15.30 – 15.45 | Iron in cardiovascular diseases, biological aspects N. Georgiou (Utrecht, The Netherlands) |
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15.45 – 16.00 | Dietary heme iron and coronary heart disease D.L. van der A, P.H.M. Peeters, D.E. Grobbee, and Y.T. van der Schouw (Utrecht, The Netherlands) |
163 |
16.00 – 16.15 | Iron modulates monocyte adherence to human endothelial cell monolayer A.E.R. Kartikasari, N.A. Georgiou, H. van Kats-Renaud, F.L.J. Visseren, B.S. van Asbeck, and J.J.M Marx (Utrecht, The Netherlands) |
164 |
16.15 – 16.30 | coffee break | |
Session IV | ||
Chairs | Z.I. Cabantchik (Jerusalem, Israel) & R.C. Hider (London, UK) | Abstract No. |
16.30 – 17.00 | Non Transferrin Bound Iron: its nature and measurement R.C. Hider, and D.Y. Liu (London, UK) |
165 |
17.00 – 17.30 | Labile Plasma Iron (LPI), a novel indicator of chemically reactive iron in iron-overload B. P. Esposito, W. Breuer, and Z.I. Cabantchik (Jerusalem, Israel) |
166 |
17.30 – 18.00 | Discussion | |
18.00 | End of Session IV | |
Session V | Friday | |
Chairs | P. Aisen (New York, USA) & W. Koppenol (Zürich, Switzerland) | Abstract No. |
9.40 – 10.10 | The uses and hazards of iron: a review of mechanisms and defenses P. Aisen (New York, USA) |
167 |
10.10 – 10.35 | Iron and redox cycling D. Hofstetter, R. Kissner, and W.H. Koppenol (Zürich, Switzerland) |
168 |
10.35 – 11.00 | Iron and radical reactions M. Merkhofer, R. Kissner, A. Vanin, and W.H. Koppenol (Zürich, Switzerland) |
169 |
11.00 – 11.15 | coffee break | |
Session VI | ||
Chairs | J.J.M. Marx (Utrecht, The Netherlands) & A. Pietrangelo (Modena, Italy) | Abstract No. |
11.15 – 11.45 | Development of orally active iron chelators for the treatment of thalassaemia R.C. Hider, and Z.D. Liu (London, UK) |
170 |
11.45 – 12.05 | Update on the clinical development of the new oral iron chelator ICL670 D. Alberti (Origgio, Italy) |
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12.05 – 13.00 | Round table discussion on toxicity of iron in biological fluids P. Aisen (New York, USA)W.H. Koppenol (Zürich, Switzerland)R.C. Hider (London, UK)Z.I. Cabantchik (Jerusalem, Israel) |
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13.00 | End of workshop |