Postprandial lipemia
11 – 13 April, 2002
Organizers J. Ribalta (Reus, Spain)
M. Castro Cabezas (Utrecht, The Netherlands)
Sponsors MSD
Astra Zeneca
Novartis
Glaxo Wellcome

Clinical and genetic aspects of postprandial lipemia

Session I

 Thursday, 11 April 2002
Chairs J. Ribalta (Reus, Spain)
M. Castro Cabezas (Utrecht, The Netherlands)
Abstract no
9.45 – 9.50 Welcome and aims of the workshop
M. Castro Cabezas, J. Ribalta
9.50 – 10.30 Historical Perspectof Historical perspective of postprandial lipemia as risk factor for atherosclerosis
The Third Donald Zilversmit LectureD.W. Erkelens (Utrecht, The Netherlands)
10.30 – 10.45 Debate: Is there need for standardization of the oral fal load
10.30-10.35: pro – Dr. Fredrik Karpe
10.35-10.40: con – Dr. Jeffrey Cohn
10.40-10.45: discussion
10.45 – 11.15 coffee break
11.15 – 11.45 Genetic Aspects of Postprandial Lipemia
J. Ordovas (Boston, USA)
11.45 – 12.15 The newly identified apolipoprotein A-V gene and diurnal triglyceridemia
L. Figuera, J. Fernández, E. Vilella, L. Masana, M. Castro Cabezas*, J. Joven, and J. Ribalta (Reus, Spain; Utrecht, The Netherlands)
61
12.15 – 12.30 discussion, end of session I
12.30 – 14.00 lunch and poster viewing

Session II

 Thursday, 11 April 2002
Chairs J. Ordovas (Boston, USA)
K.N. Frayn (Oxford, UK)

Abstract no
15.00 – 15.30 Postprandial lipemia and vascular vessel function
T.J. Rabelink (Utrecht, The Netherlands)
15.30 – 16.00 Postprandial lipemia, oxidized fat and cardiovascular disease
J.S. Cohn (Montreal, Canada)
16.00 – 16.15 Postprandial leukocyte changes may be part of the inflammatory pathogenesis of atherosclerosis
A.J.H.H.M. van Oostrom, E.J.P. de Koning, T.J. Rabelink, and M. Castro Cabezas (Utrecht, The Netherlands)
62
16.15 – 16.45 Alternative lipid transport: the insect lipoprotein system
D.J. Van der Horst and K.W. Rodenburg (Utrecht, The Netherlands)
63
16.45 – 17.00 discussion
17.00 end of session II

Session III

 Saturday, 13 April 2002
Chairs D.W. Erkelens, (Utrecht, The Netherlands)
F. Karpe (Oxford, UK)

Abstract no
9.30 – 10.00 Modulation of postprandial lipemia: tools and targets
M. Castro Cabezas (Utrecht, the Netherlands)
10.00 – 10.15 Is postprandial hyperlipidemia useful as risk factor for CVD?
plenary discussion
10.15 – 10.30 Intra-individual variations of fasting plasma lipids, apolipoproteins and postprandial lipemia in familial combined hyperlipidemia compared to controlsD. Delawi, A.J.H.H.M van Oostrom, and M. Castro Cabezas (Utrecht, the Netherlands)
64
10.30 – 10.45 Analysis of diurnal TG profiles as the expression of postprandial lipemia in non-obese, non-diabetic, normolipidemic Spanish subjects
A. Rodrigo, C. González, A.J.H.H.M. van Oostrom*, J.T. Real, M. Castro Cabezas*, J.F. Ascaso, and R. Carmena (Valencia, Spain; Utrecht, The Netherlands)
65
10.45 – 11.15 coffee break
11.15 – 11.45 Accumulation of apoB-48 and apoB-100 triglyceride-rich lipoproteins is exacerbated by hyperinsulinemia in the postprandial state in insulin-resistant patients
A. Harbis, S. Perdreau, M.C. Bernard, A.M. Lorec, H. Portugal, P. Vague and D. Lairon (Marseille, France)
66
11.45 – 12.00 Type 2 diabetic patients have increased free fatty acids in their LDL
D. Owens, C Phillips, M. Bell, P. Collins, and GH. Tomkin (Dublin, Ireland)
67
12.00 – 12.30 discussion, end of session III
12.30 – 14.00 lunch and poster viewing

Session IV

 Saturday, 13 April 2002
Chairs J. Ribalta (Reus, Spain)
M. Castro Cabezas (Utrecht, The Netherlands)

Abstract no
14.00 – 14.30 Tissue-specific metabolism of postprandial lipids and lipoproteins
Dr. F. Karpe (Oxford, UK)
14.30 – 15.00 Postprandial lipemia: parallels between fat tolerance and glucose tolerance
Prof. Dr. K.N. Frayn (Oxford, UK)
15.00 – 15.15 Gender-independent beneficial effects by expanded dose simvastatin on fasting and postprandial lipemia
C.J.M. Halkes, P.P.Th. de Jaegere, H.W.M. Plokker, D.W. Erkelens, and M. Castro Cabezas (Utrecht, The Netherlands)
68
15.15 – 15.30 General remarks and closing
J. Ribalta and M. Castro Cabezas
15.30 end of workshop 2